The kinetics and molecular modeling of the complexation of tenoxicam with cyclodextrins in solution.

نویسندگان

  • Abdelmonem Rawashdeh
  • Shehadeh Mizyed
  • Sabri Mahmoud
  • Deeb Marji
چکیده

The effect of cyclodextrins on photodegradation of tenoxicam (TEN) was studied at pH 4, 7 and 10. After 60 min of irradiation with UV light, the photodegradation was extensive. All cyclodextrins (alpha, beta, or gamma) stabilize TEN and reduce the rate of photodegradation. The largest effect of cyclodextrins is at pH 7. Molecular modeling results help to explain and manipulate the results. The results are discussed and compared with other results from previous studies.

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عنوان ژورنال:
  • Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy

دوره 71 2  شماره 

صفحات  -

تاریخ انتشار 2008